{"id":1659,"date":"2022-03-08T14:41:27","date_gmt":"2022-03-08T14:41:27","guid":{"rendered":"https:\/\/istomedica.gr\/?page_id=1659"},"modified":"2022-03-31T09:44:24","modified_gmt":"2022-03-31T09:44:24","slug":"molecular-tests","status":"publish","type":"page","link":"https:\/\/istomedica.gr\/el\/molecular-tests\/","title":{"rendered":"\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-background-position:left top;--awb-border-sizes-top:0px;--awb-border-sizes-bottom:0px;--awb-border-sizes-left:0px;--awb-border-sizes-right:0px;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:100px;--awb-padding-bottom:15px;--awb-padding-top-small:48px;--awb-padding-bottom-small:24px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column green-border rounded-border\" style=\"--awb-padding-top:40px;--awb-padding-right:60px;--awb-padding-bottom:20px;--awb-padding-left:60px;--awb-padding-right-small:25px;--awb-padding-left-small:25px;--awb-bg-color:var(--awb-color1);--awb-bg-color-hover:var(--awb-color1);--awb-bg-size:cover;--awb-border-color:var(--awb-color5);--awb-border-top:5px;--awb-border-style:solid;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"--awb-flex-grow:0;--awb-flex-grow-medium:0;--awb-flex-grow-small:0;--awb-flex-shrink:0;--awb-flex-shrink-medium:0;--awb-flex-shrink-small:0;width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-0 fusion_builder_column_inner_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-blend:overlay;--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\" style=\"--awb-font-size:16px;--awb-text-transform:none;\"><p>\u03a4\u03bf \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u03bc\u03b1\u03c2 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03cc\u03bb\u03bf \u03c4\u03bf \u03c6\u03ac\u03c3\u03bc\u03b1 \u03c4\u03c9\u03bd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b7 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5 \u03c3\u03c4\u03cc\u03c7\u03bf \u03c4\u03bf\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03cd\u03c1\u03b5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-background-position:left top;--awb-border-sizes-top:0px;--awb-border-sizes-bottom:0px;--awb-border-sizes-left:0px;--awb-border-sizes-right:0px;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:15px;--awb-padding-bottom:15px;--awb-padding-top-small:48px;--awb-padding-bottom-small:24px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-padding-top:40px;--awb-padding-right:60px;--awb-padding-bottom:20px;--awb-padding-left:60px;--awb-padding-right-small:25px;--awb-padding-left-small:25px;--awb-bg-color:var(--awb-color1);--awb-bg-color-hover:var(--awb-color1);--awb-bg-size:cover;--awb-border-color:var(--awb-color3);--awb-border-top:1px;--awb-border-right:1px;--awb-border-bottom:1px;--awb-border-left:1px;--awb-border-style:solid;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"--awb-flex-grow:0;--awb-flex-grow-medium:0;--awb-flex-grow-small:0;--awb-flex-shrink:0;--awb-flex-shrink-medium:0;--awb-flex-shrink-small:0;width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-1 fusion_builder_column_inner_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-blend:overlay;--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"accordian fusion-accordian\" style=\"--awb-border-size:1px;--awb-icon-size:13px;--awb-content-font-size:var(--awb-typography3-font-size);--awb-icon-alignment:left;--awb-hover-color:hsla(var(--awb-color6-h),var(--awb-color6-s),calc( var(--awb-color6-l) + 58% ),var(--awb-color6-a));--awb-border-color:hsla(var(--awb-color6-h),var(--awb-color6-s),calc( var(--awb-color6-l) + 40% ),var(--awb-color6-a));--awb-background-color:var(--awb-color1);--awb-divider-color:var(--awb-color3);--awb-divider-hover-color:var(--awb-color3);--awb-icon-color:var(--awb-color5);--awb-title-color:var(--awb-color5);--awb-content-color:var(--awb-color6);--awb-icon-box-color:var(--awb-color7);--awb-toggle-hover-accent-color:var(--awb-color5);--awb-toggle-active-accent-color:var(--awb-color5);--awb-title-font-family:var(--awb-typography3-font-family);--awb-title-font-weight:var(--awb-typography3-font-weight);--awb-title-font-style:var(--awb-typography3-font-style);--awb-title-font-size:var(--awb-typography3-font-size);--awb-title-letter-spacing:0px;--awb-title-line-height:1.43;--awb-content-font-family:var(--awb-typography3-font-family);--awb-content-font-weight:var(--awb-typography3-font-weight);--awb-content-font-style:var(--awb-typography3-font-style);\"><div class=\"panel-group fusion-toggle-icon-unboxed\" id=\"accordion-1659-1\"><div class=\"fusion-panel panel-default panel-83f5375ef0e0e6151 fusion-toggle-no-divider\" style=\"--awb-content-font-size:16px;--awb-content-font-family:&quot;Ubuntu&quot;;--awb-content-font-style:normal;--awb-content-font-weight:400;--awb-title-font-family:&quot;Ubuntu&quot;;--awb-title-font-weight:400;--awb-title-font-style:normal;--awb-title-font-size:18px;--awb-title-color:var(--awb-color6);\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_83f5375ef0e0e6151\"><a class=\"active\" aria-expanded=\"true\" aria-controls=\"83f5375ef0e0e6151\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-1659-1\" data-target=\"#83f5375ef0e0e6151\" href=\"#83f5375ef0e0e6151\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon fa-plus fas\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon fa-minus fas\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2<\/span><\/a><\/h4><\/div><div id=\"83f5375ef0e0e6151\" class=\"panel-collapse collapse in\" aria-labelledby=\"toggle_83f5375ef0e0e6151\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p class=\"p1\"><strong><i>\u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/i><\/strong><br \/>\n\u03a9\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bf\u03c0\u03bf\u03b9\u03b1\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c3\u03c4\u03b7\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 \u03c4\u03c9\u03bd \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1 \u03c4\u03bf\u03c5 DNA.<br \/>\n\u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03b4\u03b9\u03b1\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b9\u03ba\u03c1\u03ae\u03c2 \u03ba\u03bb\u03af\u03bc\u03b1\u03ba\u03b1\u03c2 (small-scale) \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7\u03c2 \u03ba\u03bb\u03af\u03bc\u03b1\u03ba\u03b1\u03c2\/\u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd (large-scale).<\/p>\n<p class=\"p1\">\u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03bc\u03b9\u03ba\u03c1\u03ae\u03c2 \u03ba\u03bb\u03af\u03bc\u03b1\u03ba\u03b1\u03c2 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03ad\u03bd\u03b1 (\u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c3\u03b7\u03bc\u03b5\u03af\u03bf\u03c5\/point mutation) \u03ae \u03bc\u03b5\u03c1\u03b9\u03ba\u03ac \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03bf\u03c5 \u03bc\u03b5 \u03ad\u03bd\u03b1 \u03ac\u03bb\u03bb\u03bf, \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2 \u03cc\u03c0\u03bf\u03c5 \u03ad\u03bd\u03b1 \u03ae \u03bc\u03b5\u03c1\u03b9\u03ba\u03ac \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03b1 \u03b1\u03c6\u03b1\u03b9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf DNA \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b5\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03cc\u03c0\u03bf\u03c5 \u03ad\u03bd\u03b1 \u03ae \u03bc\u03b5\u03c1\u03b9\u03ba\u03ac \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c4\u03af\u03b8\u03b5\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf DNA.<\/p>\n<p class=\"p1\">\u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7\u03c2 \u03ba\u03bb\u03af\u03bc\u03b1\u03ba\u03b1\u03c2 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03b5\u03c5\u03c1\u03b5\u03af\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03c4\u03b7 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae \u03b4\u03bf\u03bc\u03ae \u03ba\u03b1\u03b9 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03c3\u03b5\u03b9\u03c2 \u03ae \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd, \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03bf\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ad\u03c2 \u03cc\u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03b1\u03bd\u03b1\u03c4\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03b5\u03bd\u03cc\u03c2 \u03c4\u03bc\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03b1\u03bd\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c5\u03bb\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03b5 \u03bc\u03b7 \u03bf\u03bc\u03cc\u03bb\u03bf\u03b3\u03b1 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7\u03c2 \u03ba\u03bb\u03af\u03bc\u03b1\u03ba\u03b1\u03c2 \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03ae \u03b5\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ad\u03c2 \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03c9\u03bd.<\/p>\n<p class=\"p1\"><i><strong>\u039c\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7<br \/>\n<\/strong><\/i><i><\/i>\u0397 \u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 DNA \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03af\u03b8\u03b5\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u03b8\u03c5\u03bb\u03b9\u03ba\u03ad\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03ba\u03c5\u03c4\u03bf\u03c3\u03af\u03bd\u03b5\u03c2 \u03c3\u03c4\u03bf DNA \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b9\u03ad\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c7\u03c1\u03c9\u03bc\u03b1\u03c4\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7. \u03a3\u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c5\u03bd\u03b7\u03b8\u03ad\u03c3\u03c4\u03b5\u03c1\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c5\u03c0\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03ce\u03bd \u03bf\u03b3\u03ba\u03bf-\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ce\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2.<\/p>\n<p class=\"p1\"><b>\u0393\u03b1\u03bc\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03a3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/b><\/p>\n<p class=\"p1\"><i>\u039f\u03b9 \u03b3\u03b1\u03bc\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 <\/i>\u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b7\u03b8\u03bf\u03cd\u03bd \u03ba\u03b1\u03b8\u03ce\u03c2 \u03b7 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03b5\u03af\u03c4\u03b5 \u03c3\u03c4\u03bf \u03c9\u03ac\u03c1\u03b9\u03bf \u03b5\u03af\u03c4\u03b5 \u03c3\u03c4\u03bf \u03c3\u03c0\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03b6\u03c9\u03ac\u03c1\u03b9\u03bf.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p class=\"p1\"><i>\u039f\u03b9 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 <\/i>\u03b4\u03b5\u03bd \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03bd\u03b5\u03c5\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b5\u03bd\u03ce \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03ba\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c0\u03bf\u03c1\u03b1\u03b4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03bd \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-background-position:left top;--awb-border-sizes-top:0px;--awb-border-sizes-bottom:0px;--awb-border-sizes-left:0px;--awb-border-sizes-right:0px;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:15px;--awb-padding-bottom:15px;--awb-padding-top-small:0px;--awb-padding-bottom-small:24px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-flex-column green-border rounded-border\" style=\"--awb-padding-top:40px;--awb-padding-right:60px;--awb-padding-bottom:20px;--awb-padding-left:60px;--awb-padding-right-small:25px;--awb-padding-left-small:25px;--awb-bg-color:var(--awb-color1);--awb-bg-color-hover:var(--awb-color1);--awb-bg-size:cover;--awb-border-color:var(--awb-color3);--awb-border-top:1px;--awb-border-right:1px;--awb-border-bottom:1px;--awb-border-left:1px;--awb-border-style:solid;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"--awb-flex-grow:0;--awb-flex-grow-medium:0;--awb-flex-grow-small:0;--awb-flex-shrink:0;--awb-flex-shrink-medium:0;--awb-flex-shrink-small:0;width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-2 fusion_builder_column_inner_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-blend:overlay;--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"accordian fusion-accordian\" style=\"--awb-border-size:1px;--awb-icon-size:13px;--awb-content-font-size:var(--awb-typography3-font-size);--awb-icon-alignment:left;--awb-hover-color:hsla(var(--awb-color6-h),var(--awb-color6-s),calc( var(--awb-color6-l) + 58% ),var(--awb-color6-a));--awb-border-color:hsla(var(--awb-color6-h),var(--awb-color6-s),calc( var(--awb-color6-l) + 40% ),var(--awb-color6-a));--awb-background-color:var(--awb-color1);--awb-divider-color:var(--awb-color3);--awb-divider-hover-color:var(--awb-color3);--awb-icon-color:var(--awb-color5);--awb-title-color:var(--awb-color5);--awb-content-color:var(--awb-color6);--awb-icon-box-color:var(--awb-color7);--awb-toggle-hover-accent-color:var(--awb-color5);--awb-toggle-active-accent-color:var(--awb-color5);--awb-title-font-family:var(--awb-typography3-font-family);--awb-title-font-weight:var(--awb-typography3-font-weight);--awb-title-font-style:var(--awb-typography3-font-style);--awb-title-font-size:var(--awb-typography3-font-size);--awb-title-letter-spacing:0px;--awb-title-line-height:1.43;--awb-content-font-family:var(--awb-typography3-font-family);--awb-content-font-weight:var(--awb-typography3-font-weight);--awb-content-font-style:var(--awb-typography3-font-style);\"><div class=\"panel-group fusion-toggle-icon-unboxed\" id=\"accordion-1659-2\"><div class=\"fusion-panel panel-default panel-557a6f53a08059676 fusion-toggle-no-divider\" style=\"--awb-content-font-size:16px;--awb-content-font-family:&quot;Ubuntu&quot;;--awb-content-font-style:normal;--awb-content-font-weight:400;--awb-title-font-family:&quot;Ubuntu&quot;;--awb-title-font-weight:400;--awb-title-font-style:normal;--awb-title-font-size:18px;--awb-title-color:var(--awb-color6);\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_557a6f53a08059676\"><a aria-expanded=\"false\" aria-controls=\"557a6f53a08059676\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-1659-2\" data-target=\"#557a6f53a08059676\" href=\"#557a6f53a08059676\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon fa-plus fas\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon fa-minus fas\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1<\/span><\/a><\/h4><\/div><div id=\"557a6f53a08059676\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_557a6f53a08059676\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p class=\"p1\">\u0397 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03b9\u03ce\u03bd.<br \/>\n\u03a3\u03c4\u03b7\u03bd \u03b9\u03c3\u03c4\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03c9\u03bd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b9\u03c3\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03af\u03ba\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03b5\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2.<\/p>\n<p class=\"p1\">\u0395\u03bd \u03b3\u03ad\u03bd\u03b5\u03b9, \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03c9\u03bd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd \u03b5\u03be\u03c5\u03c0\u03b7\u03c1\u03b5\u03c4\u03b5\u03af \u03c4\u03c1\u03b5\u03af\u03c2 \u03c3\u03ba\u03bf\u03c0\u03bf\u03cd\u03c2, \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03b2\u03bb\u03b5\u03c8\u03b7, \u03bc\u03b5 \u03b1\u03c1\u03ba\u03b5\u03c4\u03bf\u03cd\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03bd\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03bc\u03af\u03b1 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-background-position:left top;--awb-border-sizes-top:0px;--awb-border-sizes-bottom:0px;--awb-border-sizes-left:0px;--awb-border-sizes-right:0px;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:15px;--awb-padding-bottom:15px;--awb-padding-top-small:0px;--awb-padding-bottom-small:24px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_1 1_1 fusion-flex-column green-border rounded-border\" style=\"--awb-padding-top:40px;--awb-padding-right:60px;--awb-padding-bottom:20px;--awb-padding-left:60px;--awb-padding-right-small:25px;--awb-padding-left-small:25px;--awb-bg-color:var(--awb-color1);--awb-bg-color-hover:var(--awb-color1);--awb-bg-size:cover;--awb-border-color:var(--awb-color3);--awb-border-top:1px;--awb-border-right:1px;--awb-border-bottom:1px;--awb-border-left:1px;--awb-border-style:solid;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"--awb-flex-grow:0;--awb-flex-grow-medium:0;--awb-flex-grow-small:0;--awb-flex-shrink:0;--awb-flex-shrink-medium:0;--awb-flex-shrink-small:0;width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-3 fusion_builder_column_inner_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-blend:overlay;--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"accordian fusion-accordian\" style=\"--awb-border-size:1px;--awb-icon-size:13px;--awb-content-font-size:16px;--awb-icon-alignment:left;--awb-hover-color:hsla(var(--awb-color6-h),var(--awb-color6-s),calc( var(--awb-color6-l) + 58% ),var(--awb-color6-a));--awb-border-color:hsla(var(--awb-color6-h),var(--awb-color6-s),calc( var(--awb-color6-l) + 40% ),var(--awb-color6-a));--awb-background-color:var(--awb-color1);--awb-divider-color:var(--awb-color3);--awb-divider-hover-color:var(--awb-color3);--awb-icon-color:var(--awb-color5);--awb-title-color:var(--awb-color5);--awb-content-color:var(--awb-color6);--awb-icon-box-color:var(--awb-color7);--awb-toggle-hover-accent-color:var(--awb-color5);--awb-toggle-active-accent-color:var(--awb-color5);--awb-title-font-family:&quot;Ubuntu&quot;;--awb-title-font-weight:400;--awb-title-font-style:normal;--awb-title-font-size:18px;--awb-title-letter-spacing:0px;--awb-title-line-height:1.43;--awb-content-font-family:&quot;Ubuntu&quot;;--awb-content-font-style:normal;--awb-content-font-weight:400;\"><div class=\"panel-group fusion-toggle-icon-unboxed\" id=\"accordion-1659-3\"><div class=\"fusion-panel panel-default panel-9b52fb76038fb263e fusion-toggle-no-divider\" style=\"--awb-content-font-size:16px;--awb-content-font-family:&quot;Ubuntu&quot;;--awb-title-font-family:&quot;Ubuntu&quot;;--awb-title-font-size:18px;--awb-title-color:var(--awb-color6);\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_9b52fb76038fb263e\"><a aria-expanded=\"false\" aria-controls=\"9b52fb76038fb263e\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-1659-3\" data-target=\"#9b52fb76038fb263e\" href=\"#9b52fb76038fb263e\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon fa-plus fas\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon fa-minus fas\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">\u0394\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03bf\u03af \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2<\/span><\/a><\/h4><\/div><div id=\"9b52fb76038fb263e\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_9b52fb76038fb263e\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p class=\"p1\">1) \u0391\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03c3\u03c5\u03bd\u03b4\u03c1\u03ac\u03bc\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/p>\n<p>2) \u03a3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c7\u03ae \u03ba\u03b1\u03b9 \u03ac\u03bd\u03c4\u03bb\u03b7\u03c3\u03b7 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03b9\u03ce\u03bd \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b8\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03ba\u03c1\u03b9\u03b2\u03ad\u03c3\u03c4\u03b5\u03c1\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<\/p>\n<p>3) \u039f\u03bb\u03bf\u03ad\u03bd\u03b1 \u03b1\u03c5\u03be\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03b4\u03b9\u03b1\u03b3\u03bd\u03ce\u03c3\u03b5\u03c9\u03bd \u03bf\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03c3\u03c4\u03b9\u03ba\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03bf \u039f\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03a5\u03b3\u03b5\u03af\u03b1\u03c2 (\u03a0\u039f\u03a5\/WHO) \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03bf \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03bf\u03c6\u03af\u03bb.<\/p>\n<p>4) \u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd \u03c4\u03b1\u03c5\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c5\u03c0\u03bf\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03c9\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03c9\u03bd.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-5 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-background-position:left top;--awb-border-sizes-top:0px;--awb-border-sizes-bottom:0px;--awb-border-sizes-left:0px;--awb-border-sizes-right:0px;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:15px;--awb-padding-bottom:15px;--awb-padding-top-small:0px;--awb-padding-bottom-small:24px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_1 1_1 fusion-flex-column green-border rounded-border\" style=\"--awb-padding-top:40px;--awb-padding-right:60px;--awb-padding-bottom:20px;--awb-padding-left:60px;--awb-padding-right-small:25px;--awb-padding-left-small:25px;--awb-bg-color:var(--awb-color1);--awb-bg-color-hover:var(--awb-color1);--awb-bg-size:cover;--awb-border-color:var(--awb-color3);--awb-border-top:1px;--awb-border-right:1px;--awb-border-bottom:1px;--awb-border-left:1px;--awb-border-style:solid;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"--awb-flex-grow:0;--awb-flex-grow-medium:0;--awb-flex-grow-small:0;--awb-flex-shrink:0;--awb-flex-shrink-medium:0;--awb-flex-shrink-small:0;width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-4 fusion_builder_column_inner_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-blend:overlay;--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"accordian fusion-accordian\" style=\"--awb-border-size:1px;--awb-icon-size:13px;--awb-content-font-size:16px;--awb-icon-alignment:left;--awb-hover-color:hsla(var(--awb-color6-h),var(--awb-color6-s),calc( var(--awb-color6-l) + 58% ),var(--awb-color6-a));--awb-border-color:hsla(var(--awb-color6-h),var(--awb-color6-s),calc( var(--awb-color6-l) + 40% ),var(--awb-color6-a));--awb-background-color:var(--awb-color1);--awb-divider-color:var(--awb-color3);--awb-divider-hover-color:var(--awb-color3);--awb-icon-color:var(--awb-color5);--awb-title-color:var(--awb-color5);--awb-content-color:var(--awb-color6);--awb-icon-box-color:var(--awb-color7);--awb-toggle-hover-accent-color:var(--awb-color5);--awb-toggle-active-accent-color:var(--awb-color5);--awb-title-font-family:&quot;Ubuntu&quot;;--awb-title-font-weight:400;--awb-title-font-style:normal;--awb-title-font-size:18px;--awb-title-letter-spacing:0px;--awb-title-line-height:1.43;--awb-content-font-family:&quot;Ubuntu&quot;;--awb-content-font-style:normal;--awb-content-font-weight:400;\"><div class=\"panel-group fusion-toggle-icon-unboxed\" id=\"accordion-1659-4\"><div class=\"fusion-panel panel-default panel-a25a0a08581eb3cb0 fusion-toggle-no-divider\" style=\"--awb-content-font-size:16px;--awb-content-font-family:&quot;Ubuntu&quot;;--awb-title-font-family:&quot;Ubuntu&quot;;--awb-title-font-size:18px;--awb-title-color:var(--awb-color6);\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_a25a0a08581eb3cb0\"><a aria-expanded=\"false\" aria-controls=\"a25a0a08581eb3cb0\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-1659-4\" data-target=\"#a25a0a08581eb3cb0\" href=\"#a25a0a08581eb3cb0\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon fa-plus fas\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon fa-minus fas\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">\u03a0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03bf\u03af \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2<\/span><\/a><\/h4><\/div><div id=\"a25a0a08581eb3cb0\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_a25a0a08581eb3cb0\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p class=\"p1\">\u039f\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2.<\/p>\n<p>\u03a0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf\u03b9, \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c0\u03ad\u03c1\u03b1\u03bd \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03ca\u03c3\u03c4\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ae \u03c7\u03c1\u03ce\u03c3\u03b7.<\/p>\n<p>\u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b7 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03b3\u03ba\u03bf\u03bb\u03cc\u03b3\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b5\u03b1\u03bd \u03b8\u03b1 \u03b4\u03ce\u03c3\u03b5\u03b9 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae.<br \/>\n\u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1, \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03b7 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03c3\u03c4\u03bf Oncotype Dx \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b8\u03b1 \u03c0\u03c1\u03bf\u03c4\u03c1\u03ad\u03c8\u03b5\u03b9 \u03c4\u03bf\u03bd \u03bf\u03b3\u03ba\u03bf\u03bb\u03cc\u03b3\u03bf \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-6 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-background-position:left top;--awb-border-sizes-top:0px;--awb-border-sizes-bottom:0px;--awb-border-sizes-left:0px;--awb-border-sizes-right:0px;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:15px;--awb-padding-bottom:15px;--awb-padding-top-small:0px;--awb-padding-bottom-small:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_1 1_1 fusion-flex-column green-border rounded-border\" style=\"--awb-padding-top:40px;--awb-padding-right:60px;--awb-padding-bottom:20px;--awb-padding-left:60px;--awb-padding-right-small:25px;--awb-padding-left-small:25px;--awb-bg-color:var(--awb-color1);--awb-bg-color-hover:var(--awb-color1);--awb-bg-size:cover;--awb-border-color:var(--awb-color3);--awb-border-top:1px;--awb-border-right:1px;--awb-border-bottom:1px;--awb-border-left:1px;--awb-border-style:solid;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"--awb-flex-grow:0;--awb-flex-grow-medium:0;--awb-flex-grow-small:0;--awb-flex-shrink:0;--awb-flex-shrink-medium:0;--awb-flex-shrink-small:0;width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-5 fusion_builder_column_inner_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-blend:overlay;--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"accordian fusion-accordian\" style=\"--awb-border-size:1px;--awb-icon-size:13px;--awb-content-font-size:16px;--awb-icon-alignment:left;--awb-hover-color:hsla(var(--awb-color6-h),var(--awb-color6-s),calc( var(--awb-color6-l) + 58% ),var(--awb-color6-a));--awb-border-color:hsla(var(--awb-color6-h),var(--awb-color6-s),calc( var(--awb-color6-l) + 40% ),var(--awb-color6-a));--awb-background-color:var(--awb-color1);--awb-divider-color:var(--awb-color3);--awb-divider-hover-color:var(--awb-color3);--awb-icon-color:var(--awb-color5);--awb-title-color:var(--awb-color5);--awb-content-color:var(--awb-color6);--awb-icon-box-color:var(--awb-color7);--awb-toggle-hover-accent-color:var(--awb-color5);--awb-toggle-active-accent-color:var(--awb-color5);--awb-title-font-family:&quot;Ubuntu&quot;;--awb-title-font-weight:400;--awb-title-font-style:normal;--awb-title-font-size:18px;--awb-title-letter-spacing:0px;--awb-title-line-height:1.43;--awb-content-font-family:&quot;Ubuntu&quot;;--awb-content-font-style:normal;--awb-content-font-weight:400;\"><div class=\"panel-group fusion-toggle-icon-unboxed\" id=\"accordion-1659-5\"><div class=\"fusion-panel panel-default panel-ca31c1d40f017a774 fusion-toggle-no-divider\" style=\"--awb-content-font-size:16px;--awb-content-font-family:&quot;Ubuntu&quot;;--awb-content-font-style:normal;--awb-content-font-weight:400;--awb-title-font-family:&quot;Ubuntu&quot;;--awb-title-font-weight:400;--awb-title-font-style:normal;--awb-title-font-size:18px;--awb-title-color:var(--awb-color6);\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_ca31c1d40f017a774\"><a aria-expanded=\"false\" aria-controls=\"ca31c1d40f017a774\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-1659-5\" data-target=\"#ca31c1d40f017a774\" href=\"#ca31c1d40f017a774\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon fa-plus fas\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon fa-minus fas\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">\u03a0\u03c1\u03bf\u03b2\u03bb\u03b5\u03c0\u03c4\u03b9\u03ba\u03bf\u03af \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2<\/span><\/a><\/h4><\/div><div id=\"ca31c1d40f017a774\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_ca31c1d40f017a774\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p class=\"p1\">\u039f\u03b9 \u03c0\u03c1\u03bf\u03b2\u03bb\u03b5\u03c0\u03c4\u03b9\u03ba\u03bf\u03af \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03ba\u03b1\u03c4\u03ac \u03b2\u03ac\u03c3\u03b7 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bd \u03c3\u03b5 \u03c0\u03bf\u03b9\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03b8\u03b1 \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03b9\u03b8\u03b5\u03af \u03bf \u03cc\u03b3\u03ba\u03bf\u03c2.<\/p>\n<p class=\"p1\"><b><i>\u0394\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/i><\/b><br \/>\n\u03a3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5, \u03bf\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03c3\u03c4\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<br \/>\n\u0397 \u03b1\u03b3\u03c9\u03b3\u03ae \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9:<br \/>\n1) \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2<br \/>\n2) \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03b5\u03c1\u03af\u03bd\u03b7\u03c2\/\u03b8\u03c1\u03b5\u03bf\u03bd\u03af\u03bd\u03b7\u03c2<br \/>\n3) \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 GTP\u03b1\u03c3\u03b7\u03c2<br \/>\n4) \u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ac 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\u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c3\u03c4\u03b7\u03bd \u03af\u03b1\u03c3\u03ae \u03c4\u03bf\u03c5 (cure).<\/p>\n<p class=\"p1\">\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf \u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c3\u03c4\u03b1\u03b4\u03b9\u03b1\u03ba\u03ac \u03b1\u03c0\u03bf\u03ba\u03c4\u03ac \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (\u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 1 \u03bc\u03b5 2 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03ae \u03c4\u03b7\u03c2):<br \/>\n1) \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03be\u03bf\u03c5\u03bd \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9<br \/>\n2) \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03be\u03bf\u03c5\u03bd \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 (\u03c0.\u03c7 \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7)<br \/>\n3) \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03be\u03bf\u03c5\u03bd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03bc\u03c0\u03c4\u03bf\u03c5\u03bd \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9.<\/p>\n<p class=\"p1\"><b><i>\u0394\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/i><\/b><\/p>\n<p class=\"p1\">\u0397 \u03b1\u03b3\u03c9\u03b3\u03ae \u03bc\u03b5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c7\u03b5\u03b9\u03c1\u03b1\u03b3\u03c9\u03b3\u03b5\u03af \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ce\u03c3\u03c4\u03b5 \u03b1\u03c5\u03c4\u03cc \u03bd\u03b1 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5.<br \/>\n\u03a4\u03b1 \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03b1\u03bd\u03bf\u03c3\u03b9\u03b1\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03bc\u03cc\u03c1\u03b9\u03b1 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03c1\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7.<br \/>\n\u039f\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 (\u0391\u03a3\u0395) \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c4\u03cd\u03c0\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd \u03b1\u03bd\u03bf\u03c3\u03b9\u03b1\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5. \u03a9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b1\u03c0\u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c3\u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03bd\u03b1 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c4\u03b1 \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<br \/>\n\u039f\u03b9 \u0391\u03a3\u0395 \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03c3\u03c4\u03bf \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03bf \u03bd\u03b5\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1 \u03cd\u03c0\u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03bf\u03bb\u03bf\u03ad\u03bd\u03b1 \u03b1\u03c5\u03be\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c3\u03c4\u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<br \/>\n\u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03b2\u03bb\u03b5\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd:<br \/>\n1) \u03a4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 PDL-1 \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ca\u03c3\u03c4\u03bf\u03c7\u03b7\u03bc\u03b5\u03af\u03b1\u03c2 (\u03c0.\u03c7 \u03bc\u03b7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1 (NSCLC), \u03c0\u03bb\u03b1\u03ba\u03ce\u03b4\u03b5\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1 \u03ba\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2-\u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5, \u03bf\u03c5\u03c1\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1, \u03c4\u03c1\u03b9\u03c0\u03bb\u03ac \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03bf\u03b9\u03c3\u03bf\u03c6\u03ac\u03b3\u03bf\u03c5)<br \/>\n2) \u03a4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b2\u03bb\u03b1\u03b2\u03ce\u03bd \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA (MMR), \u03cc\u03c0\u03c9\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5, \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03bc\u03b7\u03c4\u03c1\u03af\u03bf\u03c5, \u03c3\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03bf\u03c5 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03bf\u03c7\u03bf\u03bb\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2.<br \/>\n3) \u03a4\u03b7\u03bd \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c6\u03bf\u03c1\u03c4\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 (TMB) \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-7 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-background-position:left top;--awb-border-sizes-top:0px;--awb-border-sizes-bottom:0px;--awb-border-sizes-left:0px;--awb-border-sizes-right:0px;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:15px;--awb-padding-bottom:15px;--awb-padding-top-small:48px;--awb-padding-bottom-small:24px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_1 1_1 fusion-flex-column green-border rounded-border\" style=\"--awb-padding-top:40px;--awb-padding-right:60px;--awb-padding-bottom:20px;--awb-padding-left:60px;--awb-padding-right-small:30px;--awb-padding-left-small:30px;--awb-bg-color:var(--awb-color1);--awb-bg-color-hover:var(--awb-color1);--awb-bg-size:cover;--awb-border-color:var(--awb-color4);--awb-border-top:5px;--awb-border-style:solid;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-2\" style=\"--awb-font-size:24px;--awb-line-height:30px;--awb-text-transform:capitalize;--awb-text-font-family:&quot;Ubuntu&quot;;--awb-text-font-style:normal;--awb-text-font-weight:700;\"><p>\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2<\/p>\n<\/div><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"--awb-flex-grow:0;--awb-flex-grow-medium:0;--awb-flex-grow-small:0;--awb-flex-shrink:0;--awb-flex-shrink-medium:0;--awb-flex-shrink-small:0;width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-6 fusion_builder_column_inner_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-blend:overlay;--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-3 modal_links\" style=\"--awb-text-transform:none;\"><p class=\"p1\"><span class=\"s1\"><span style=\"color: #43aed6;\"><b>\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03a0\u03b1\u03c7\u03ad\u03bf\u03c2 \u0395\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5: <\/b><\/span><br \/>\n<\/span>1) \u0391\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03bf\u03c1\u03c5\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c3\u03c4\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2 <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.msi-modal\" href=\"#\">(MSI)<\/a><span class=\"s1\"><br \/>\n<\/span>2) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.kras-modal\" href=\"#\">KRAS<\/a> \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<span class=\"s1\"><br \/>\n<\/span>3) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.nras-modal\" href=\"#\">NRAS<\/a> \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<span class=\"s1\"><br \/>\n<\/span>4) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.braf-modal\" href=\"#\">BRAF<\/a> \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<span class=\"s1\"><br \/>\n<\/span>5) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.panel-prodiathesis-karkinou-modal\" href=\"#\">Panel \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5<\/a><\/p>\n<p class=\"p1\"><span class=\"s1\"><span style=\"color: #43aed6;\"><b>K\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf\u03c2 \u03bc\u03b7 \u03c0\u03bf\u03bb\u03c5\u03c0\u03bf\u03b4\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b8\u03bf\u03cd (HNPCC)-\u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Lynch<\/b><\/span><br \/>\n<\/span>1) \u0391\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03bf\u03c1\u03c5\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c3\u03c4\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2 <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.msi-modal\" href=\"#\">(MSI)<\/a><span class=\"s1\"><br \/>\n<\/span>2) \u0391\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c4o\u03c5 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.mmr-modal\" href=\"#\">MMR<\/a><span class=\"s1\"><br \/>\n<\/span>3) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.braf-modal\" href=\"#\">BRAF<\/a> V600E\/K<span class=\"s1\"><br \/>\n<\/span>4) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.panel-sindromou-lynch-modal\" href=\"#\">Panel \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 Lynch<\/a><\/p>\n<p class=\"p1\"><span class=\"s1\"><span style=\"color: #43aed6;\"><b>\u039f\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03b1\u03b4\u03b5\u03bd\u03bf\u03bc\u03b1\u03c4\u03ce\u03b4\u03b7\u03c2 \u03c0\u03bf\u03bb\u03c5\u03c0\u03bf\u03b4\u03af\u03b1\u03c3\u03b7 (FAP)<\/b><\/span><br \/>\n<\/span>1) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.apc-modal\" href=\"#\">APC<\/a><span class=\"s1\"><br \/>\n<\/span>2) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.panel-sindromou-polipodiasis-modal\" href=\"#\">Panel \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03c0\u03bf\u03bb\u03c5\u03c0\u03bf\u03b4\u03af\u03b1\u03c3\u03b7\u03c2<\/a><\/p>\n<p class=\"p1\"><span class=\"s1\"><span style=\"color: #43aed6;\"><b>\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd\/\u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd (high-grade)<\/b><\/span><br \/>\n<\/span>1) \u0395\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b2\u03b9\u03bf\u03b4\u03b5\u03af\u03ba\u03c4\u03b7 <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.her-2-modal\" href=\"#\">HER-2<\/a> <span class=\"s1\"><br \/>\n<\/span>2) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.brca1-2-modal\" href=\"#\">BRCA1\/2 <\/a> &#8211; \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<span class=\"s1\"><br \/>\n<\/span>3) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.brca1-2-modal\" href=\"#\">BRCA1\/2 <\/a> &#8211; MLPA (\u03b5\u03bb\u03bb\u03b5\u03af\u03c8\u03b5\u03b9\u03c2\/\u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03bf\u03af)<span class=\"s1\"><br \/>\n<\/span>4) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.brca1-2-modal\" href=\"#\">BRCA1\/2 <\/a> \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 MLPA (\u03b5\u03bb\u03bb\u03b5\u03af\u03c8\u03b5\u03b9\u03c2\/\u03b4\u03b9\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03bf\u03af)<span class=\"s1\"><br \/>\n<\/span>5) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.brca1-2-modal\" href=\"#\">BRCA1\/2 <\/a><span class=\"s2\">\u00a0\u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/span><span class=\"s1\"><br \/>\n<\/span><span class=\"s2\">6) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.panel-prodiathesis-karkinou-mastou-modal\" href=\"#\">Panel \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd\/\u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd<\/a><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><span style=\"color: #43aed6;\"><b>\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2<\/b><\/span><br \/>\n<\/span><span class=\"s2\"><a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.hpv-anixneusi-modal\" href=\"#\"><\/span>HPV<span class=\"s2\"><\/a> <\/span>\u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03c5\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7<\/p>\n<p class=\"p1\"><span class=\"s1\"><span style=\"color: #43aed6;\"><b>\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2<\/b><\/span><br \/>\n<\/span>1. <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.braf-modal\" href=\"#\">BRAF<\/a> V600E\/K<span class=\"s1\"><br \/>\n<\/span>2. <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.ret-modal\" href=\"#\">RET<\/a> (MEN2)<\/p>\n<p class=\"p2\"><span style=\"color: #43aed6;\"><b>\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2<\/b><\/span><\/p>\n<p class=\"p2\"><a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.men1-modal\" href=\"#\">MEN1<\/a><\/p>\n<p class=\"p1\"><span class=\"s1\"><span style=\"color: #43aed6;\"><b>\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03ba\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2\/\u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5<\/b><\/span><br \/>\n<\/span><a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.egfr-modal\" href=\"#\">EGFR<\/a> (\u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7)(7p12)<\/p>\n<p class=\"p2\"><span style=\"color: #43aed6;\"><b>\u0386\u03c4\u03c5\u03c0\u03bf\u03c2 \u03bb\u03b9\u03c0\u03c9\u03bc\u03b1\u03c4\u03ce\u03b4\u03b7\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c2\/\u03ba\u03b1\u03bb\u03ac \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03bb\u03b9\u03c0\u03bf\u03c3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1<\/b><\/span><br \/>\n<span class=\"s3\"><a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.mdm2-modal\" href=\"#\">MDM2<\/a> (12q14-q15) \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><span style=\"color: #43aed6;\"><b>\u039c\u03b7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1<\/b><\/span><br \/>\n<\/span>1) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.egfr-modal\" href=\"#\">EGFR<\/a> \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7<span class=\"s1\"><br \/>\n<\/span>2) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.braf-modal\" href=\"#\">BRAF<\/a> V600E\/K<span class=\"s1\"><br \/>\n<\/span>3) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.kras-modal\" href=\"#\">KRAS<\/a> \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7<span class=\"s1\"><br \/>\n<\/span>4) <span class=\"s3\"><a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.alk-modal\" href=\"#\">ALK<\/a> \u03b1\u03bd\u03b1\u03ba\u03b1\u03c4\u03b1\u03c4\u03ac\u03be\u03b5\u03b9\u03c2<\/span><span class=\"s1\"><br \/>\n<\/span>5) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.ros1-modal\" href=\"#\">ROS1<\/a> \u03b1\u03bd\u03b1\u03ba\u03b1\u03c4\u03b1\u03c4\u03ac\u03be\u03b5\u03b9\u03c2<span class=\"s1\"><br \/>\n<\/span>6) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.ret-modal\" href=\"#\">RET<\/a> \u03b1\u03bd\u03b1\u03ba\u03b1\u03c4\u03b1\u03c4\u03ac\u03be\u03b5\u03b9\u03c2<span class=\"s1\"><br \/>\n<\/span>7) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.nrtk-modal\" href=\"#\">NTRK<\/a> \u03c3\u03cd\u03bd\u03c4\u03b7\u03be\u03b7<span class=\"s1\"><br \/>\n<\/span>8) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.pd-l1-modal\" href=\"#\">PD-L1<\/a> \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7<span class=\"s1\"><br \/>\n<\/span>9) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.pik3ca-modal\" href=\"#\">PIK3CA-5<\/a> \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<span class=\"s1\"><br \/>\n<\/span>10) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.pik3ca-modal\" href=\"#\">PIK3CA-11<\/a> \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<span class=\"s1\"><br \/>\n<\/span>12) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.met-modal\" href=\"#\">MET<\/a> \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7<span class=\"s1\"><br \/>\n<\/span>13) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.fgfr1\u2028-modal\" href=\"#\">FGFR1 <\/a> \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae<\/p>\n<p class=\"p1\"><span class=\"s1\"><span style=\"color: #43aed6;\"><b>\u039c\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1<\/b><\/span><br \/>\n<\/span>1) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.braf-modal\" href=\"#\">BRAF<\/a> V600E\/K<span class=\"s1\"><br \/>\n<\/span>2) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.braf-modal\" href=\"#\">BRAF<\/a> (\u03cc\u03bb\u03b1 \u03c4\u03b1 \u03b5\u03be\u03ce\u03bd\u03b9\u03b1)<span class=\"s1\"><br \/>\n<\/span>3) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.nras-modal\" href=\"#\">NRAS<\/a> (\u03b5\u03be\u03ce\u03bd\u03b9\u03b1 2,3,4)<span class=\"s1\"><br \/>\n<\/span>4) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.panel-prodiathesis-melanwmatos-modal\" href=\"#\">Panel \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03bf\u03c5\u03c2 \u03bc\u03b5\u03bb\u03b1\u03bd\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2<\/a><\/p>\n<p class=\"p2\"><span style=\"color: #43aed6;\"><b>\u03a3\u03c4\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03af \u03cc\u03b3\u03ba\u03bf\u03b9 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 (GIST)<\/b><\/span><br \/>\n<span class=\"s3\">1) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.kit-modal\" href=\"#\">KIT<\/a> \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7<\/span><br \/>\n<span class=\"s3\">2) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.pdgfra-modal\" href=\"#\">PDGFRA<\/a> \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7<span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n<p class=\"p2\"><span style=\"color: #43aed6;\"><b>\u039f\u03c5\u03c1\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1<\/b><\/span><br \/>\n<span class=\"s3\">1)<a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.pd-l1-modal\" href=\"#\">PD-L1<\/a> \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><span style=\"color: #43aed6;\"><b>\u0391\u03b4\u03b5\u03bd\u03bf\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1 \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03bf\u03c5<\/b><\/span><br \/>\n1<\/span>) \u0395\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b2\u03b9\u03bf\u03b4\u03b5\u03af\u03ba\u03c4\u03b7 <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.her-2-modal\" href=\"#\">HER-2\/neu<\/a><span class=\"s1\"><br \/>\n<\/span>2) <a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.panel-prodiathesis-gastrikou-karkinou-modal\" href=\"#\">Panel \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5<\/a><\/p>\n<p class=\"p1\"><span class=\"s1\"><span style=\"color: #43aed6;\"><b>\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2<\/b><\/span><br \/>\n<\/span><a class=\"fusion-modal-text-link\" data-toggle=\"modal\" data-target=\".fusion-modal.panel-prodiathesis-karkinou-pagkreatos-modal\" href=\"#\">Panel \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-8 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-7 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-modal modal fade modal-1 alk-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-1\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-1\" data-dismiss=\"modal\" aria-hidden=\"true\">ALK<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9: <\/b>\u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf ALK \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03ad\u03bd\u03b1\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b1 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 RAF, RAS \u03ba\u03b1\u03b9 MEK.<br \/>\n\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc\u03c2 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2.<br \/>\n\u0394\u03b9\u03b1\u03bc\u03b5\u03c4\u03b1\u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 ALK \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c4\u03bf \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c3\u03b5 \u03c3\u03cd\u03b6\u03b5\u03c5\u03be\u03b7 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 (\u03c0.\u03c7 ALK-EML4) \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 ALK \u03c9\u03c2 \u03c4\u03bc\u03ae\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b7\u03c2.<\/p>\n<p class=\"p1\"><b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7: <\/b>\u03a3\u03c4\u03bf \u03bc\u03b7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1, \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 ALK \u03b4\u03b9\u03b1\u03bc\u03b5\u03c4\u03b1\u03b8\u03ad\u03c3\u03b7\u03c2 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03af\u03bd\u03b7\u03c2 (TKIs) (\u03c0.\u03c7 Crizotinib, Ceritinib, Alectinib)<\/p>\n<p class=\"p1\"><b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1: <\/b>\u03a0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 2% \u03c4\u03c9\u03bd \u03bc\u03b7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1.<br \/>\n\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03b1 \u03b2\u03bb\u03b5\u03bd\u03bd\u03ce\u03b4\u03b7 \u03b1\u03b4\u03b5\u03bd\u03bf\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1.<br \/>\n\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bc\u03b7 \u03ba\u03b1\u03c0\u03bd\u03b9\u03c3\u03c4\u03b5\u03c2.<br \/>\n\u03a3\u03c0\u03b1\u03bd\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b1 \u03c0\u03bb\u03b1\u03ba\u03ce\u03b4\u03b7 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1.<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-2 fgfr1\u2028-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-2\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-2\" data-dismiss=\"modal\" aria-hidden=\"true\">FGFR1\u2028<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><span class=\"s1\"><b>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9: <\/b>\u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf FGFR1 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03ad\u03bd\u03b1\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b1 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 RAF, RAS \u03ba\u03b1\u03b9 MEK. <\/span><br \/>\n<span class=\"s1\">\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc\u03c2 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2. <\/span><br \/>\n<span class=\"s1\">\u039f\u03b9 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 FGFR1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03b9\u03c2 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf\u03bd \u03bc\u03b7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 EGFR \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b4\u03b9\u03b1\u03bc\u03b5\u03c4\u03b1\u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd ALK, ROS1 \u03ba\u03b1\u03b9 RET.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7: <\/b>\u03a3\u03c4\u03bf \u03bc\u03b7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1 \u03b7 \u03b1\u03bd\u03b5\u03cd\u03c1\u03b5\u03c3\u03b7 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae\u03c2 \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 FGFR1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ad\u03bd\u03b1\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b2\u03b9\u03bf\u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1: <\/b>\u0397 \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 FGFR1 \u03b1\u03bd\u03b5\u03c5\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 20% \u03c4\u03c9\u03bd \u03c0\u03bb\u03b1\u03ba\u03c9\u03b4\u03ce\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1.<\/span><\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-3 apc-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-3\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-3\" data-dismiss=\"modal\" aria-hidden=\"true\">APC<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><span class=\"s1\"><b>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9: <\/b>\u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf APC \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03af\u03bd\u03b7 APC \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03c5\u03c1\u03af\u03b1\u03c1\u03c7\u03bf \u03c1\u03cc\u03bb\u03bf \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03c0\u03bb\u03b7\u03b8\u03ce\u03c1\u03b1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ce\u03bd \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03b9\u03ce\u03bd. \u03a0\u03b9\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bf\u03b3\u03ba\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03c4\u03bf\u03bd \u03b1\u03bd\u03b5\u03be\u03ad\u03bb\u03b5\u03b3\u03ba\u03c4\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7: <\/b>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b5\u03bb\u03b5\u03b3\u03c7\u03b8\u03b5\u03af \u03b7 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03b3\u03bd\u03c9\u03c3\u03c4\u03bf\u03cd \u03c9\u03c2 \u039f\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u0391\u03b4\u03b5\u03bd\u03c9\u03bc\u03b1\u03c4\u03ce\u03b4\u03b7\u03c2 \u03a0\u03bf\u03bb\u03c5\u03c0\u03bf\u03b4\u03af\u03b1\u03c3\u03b7 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03cc \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03ae \u03c4\u03c1\u03cc\u03c0\u03bf. \u03a4\u03bf \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b4\u03b5\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c4\u03bf\u03c5 APC I1307K.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\"><b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1:<\/b> \u03a4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03bc\u03b5 \u039f\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae \u0391\u03b4\u03b5\u03bd\u03c9\u03bc\u03b1\u03c4\u03ce\u03b4\u03b7 \u03a0\u03bf\u03bb\u03c5\u03c0\u03bf\u03b4\u03af\u03b1\u03c3\u03b7 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc 1 \u03c3\u03c4\u03bf\u03c5\u03c2 22.000 \u03ad\u03c9\u03c2 1 \u03c3\u03c4\u03bf\u03c5\u03c2 7.000, \u03b5\u03bd\u03ce \u03ad\u03bd\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd, \u03c0\u03b5\u03c1\u03af \u03c4\u03bf 30%, \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03c0\u03c1\u03ce\u03c4\u03bf\u03b9 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7.<\/span><\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-4 braf-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-4\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-4\" data-dismiss=\"modal\" aria-hidden=\"true\">BRAF<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9:<\/b> \u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf BRAF \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b7 B-Raf \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2. \u0397 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc.<br \/>\n\u0397 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ae \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c4\u03b7\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd V600E.<\/p>\n<p class=\"p1\"><b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7: <\/b><br \/>\n<b>\u039c\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1: <\/b>\u0397 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 BRAF V600E \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 BRAF \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u039c\u0395\u039a.<br \/>\n<b>\u039c\u039c\u039a\u03a0: <\/b>\u0397 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 BRAF V600E \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 BRAF \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u039c\u0395\u039a.<br \/>\n<b>\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5: <\/b>\u0397 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 BRAF V600E \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc BRAF \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03bc\u03b5 EGFR \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1.<br \/>\n<b>\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2: <\/b><br \/>\n1. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 BRAF V600E \u03c3\u03c4\u03bf \u03b8\u03b7\u03bb\u03ce\u03b4\u03b5\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2.<br \/>\n2. \u03a3\u03c4\u03bf \u03b1\u03bd\u03b1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 BRAF V600E \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 BRAF (dabrafenib) \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u039c\u0395\u039a (trametinib).<br \/>\n3. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03c3\u03c4\u03bf BRAF V600E \u03c3\u03c5\u03bd\u03c5\u03b3\u03bf\u03c1\u03b5\u03af \u03c5\u03c0\u03ad\u03c1 \u03b8\u03b7\u03bb\u03ce\u03b4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03c5\u03c0\u03bf\u03c4\u03cd\u03c0\u03c9\u03bd.<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1: <\/b><br \/>\n<b>\u039c\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1: <\/b>\u03a0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c4\u03bf 50% \u03c4\u03c9\u03bd \u03bc\u03b5\u03bb\u03b1\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c4\u03bf\u03c5 BRAF, \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03bb\u03cc\u03b3\u03c9 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03b1\u03ba\u03ae \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1.<br \/>\n<b>\u039c\u039c\u039a\u03a0:<\/b> \u03a3\u03b5 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc 5% \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd. \u03a0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bc\u03b7-\u03ba\u03b1\u03c0\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b1\u03b4\u03b5\u03bd\u03bf\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b8\u03b7\u03bb\u03ce\u03b4\u03b5\u03c2 \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2.<br \/>\n<b>\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5:<\/b> \u03a0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf 10% \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd. \u039c\u03bf\u03b9\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03bf\u03b1\u03bd\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5 \u03bc\u03b5 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b1\u03c4\u03b1\u03af\u03c1\u03b9\u03b1\u03c3\u03c4\u03c9\u03bd \u03b2\u03ac\u03c3\u03b5\u03c9\u03bd (dMMR).<br \/>\n<b>\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2: <\/b>\u0391\u03bd\u03b5\u03c5\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 50% \u03c4\u03c9\u03bd \u03b8\u03b7\u03bb\u03c9\u03b4\u03ce\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2, \u03c3\u03c4\u03bf 20% \u03c4\u03c9\u03bd \u03b1\u03bd\u03b1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c0\u03b9\u03bf \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b9\u03c3\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c5\u03c0\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5\u03c2 (\u03c0.\u03c7 tall cell).<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-5 brca1-2-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-5\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-5\" data-dismiss=\"modal\" aria-hidden=\"true\">BRCA1\/2<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9: <\/b>\u03a4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 BRCA1\/2 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b5\u03c2 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03b2\u03bb\u03b1\u03b2\u03ce\u03bd \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03ba\u03cd\u03c8\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b4\u03cd\u03bf \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03c4\u03bf\u03c5 DNA \u03bc\u03ad\u03c3\u03c9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd. \u0395\u03ac\u03bd \u03c4\u03b1 BRCA1\/2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03c4\u03cc\u03c4\u03b5 \u03bf\u03b9 \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03c4\u03bf\u03c5 DNA \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9.<br \/>\n\u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 BRCA1 \u03ba\u03b1\u03b9 BRCA2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c8\u03bf\u03c5\u03bd \u03b5\u03af\u03c4\u03b5 \u03b1\u03c0\u03cc \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ad\u03c2 (\u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03b5\u03c2) \u03ae \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/b>:<br \/>\n1. \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 BRCA1\/2<span class=\"Apple-converted-space\">\u00a0 <\/span>\u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 PARP.<br \/>\n2. \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd. \u039f\u03b9 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03bc\u03b5 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 BRCA \u03ad\u03c7\u03bf\u03c5\u03bd \u03c9\u03c2 \u03ba\u03b1\u03b9 40% \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03be\u03bf\u03c5\u03bd \u03ad\u03bd\u03b1 \u03bd\u03ad\u03bf \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 10 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b5\u03ac\u03bd \u03b4\u03b5\u03bd \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1: <\/b><br \/>\n1. \u03a0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 25% \u03c4\u03c9\u03bd \u03c5\u03c8\u03b7\u03bb\u03cc\u03b2\u03b1\u03b8\u03bc\u03b7\u03c2 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u03c2 \u03bf\u03c1\u03c9\u03b4\u03ce\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03c9\u03bf\u03b8\u03ae\u03ba\u03b7\u03c2<br \/>\n2. \u0397 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd BRCA1\/2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03b1\u03bd\u03b5\u03c5\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc 5-7% \u03c3\u03c4\u03b7\u03bd \u03ba\u03bf\u03b9\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1.<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-6 egfr-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-6\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-6\" data-dismiss=\"modal\" aria-hidden=\"true\">EGFR<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9:<\/b> \u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf EGFR (epidermal growth factor receptor) \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03ad\u03bd\u03b1\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03ce\u03bd RAS, RAF \u03ba\u03b1\u03b9 MEK, \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03b5\u03be\u03ad\u03bb\u03b5\u03b3\u03ba\u03c4\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc. \u039f\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c4\u03bf L858R \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03be\u03c9\u03bd\u03af\u03bf\u03c5 19. \u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03b5\u03be\u03ce\u03bd\u03b9\u03bf 20 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2. \u0395\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 T790M \u03c3\u03c4\u03bf \u03b5\u03be\u03ce\u03bd\u03b9\u03bf 20 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ac\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 (TKIs) \u03b1\u03bb\u03bb\u03ac \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c4\u03c1\u03af\u03c4\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ac\u03c2 TKIs (osimertinib).<\/p>\n<p class=\"p1\"><b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/b>: \u03a3\u03c4\u03bf \u039c\u039c\u039a\u03a0 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 EGFR \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2.<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1:<\/b> \u03a0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf 10-15% \u03c4\u03bf\u03c5 \u0394\u03c5\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03cc\u03c3\u03bc\u03bf\u03c5<br \/>\n1. \u039a\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b7-\u03ba\u03b1\u03c0\u03bd\u03af\u03c3\u03c4\u03c1\u03b9\u03b5\u03c2<br \/>\n2. \u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b7\u03bd \u0391\u03bd\u03b1\u03c4\u03bf\u03bb\u03b9\u03ba\u03ae \u0391\u03c3\u03af\u03b1<br \/>\n3. \u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b1 \u03b1\u03b4\u03b5\u03bd\u03bf\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1, \u03ba\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b1 \u03ba\u03b1\u03bb\u03ac \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-7 her-2-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-7\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-7\" data-dismiss=\"modal\" aria-hidden=\"true\">HER-2<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9: <\/b>\u03a4\u03bf HER-2 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03ad\u03bd\u03b1\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b1 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 RAS, RAF \u03ba\u03b1\u03b9 \u039c\u0395\u039a \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc. \u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03b7 \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u0397\u0395R-2 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b7\u03c2 \u03ba\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03b5\u03c0\u03b9\u03c1\u03c1\u03b5\u03c0\u03ad\u03c2 \u03c3\u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 HER-2 \u03ba\u03b1\u03b9 \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03b1\u03bd\u03b5\u03be\u03ad\u03bb\u03b5\u03b3\u03ba\u03c4\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7: <\/b>\u03a3\u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03bf\u03c5, \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5, \u03c4\u03c9\u03bd \u03c3\u03b9\u03b5\u03bb\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03b1\u03b4\u03ad\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b5\u03bd\u03b4\u03bf\u03bc\u03b7\u03c4\u03c1\u03b9\u03ba\u03ac \u03bf\u03c1\u03ce\u03b4\u03b7 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b2\u03b9\u03bf\u03b4\u03b5\u03af\u03ba\u03c4\u03b7 HER-2 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 anti-HER-2 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (\u03c0.\u03c7 trastuzumab, pertuzumab).<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1: <\/b><br \/>\n1. \u03a3\u03c4\u03bf 20% \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd; \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b1 \u03c5\u03c8\u03b7\u03bb\u03cc\u03b2\u03b1\u03b8\u03bc\u03b7\u03c2 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u03c2 (Grade) \u03b1\u03b4\u03b5\u03bd\u03bf\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03ae\u03c1\u03b5\u03c2 (NST)<br \/>\n2. \u03a3\u03c4\u03bf 10-20% \u03c4\u03c9\u03bd \u03b1\u03b4\u03b5\u03bd\u03bf\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03bf\u03c5; \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03c4\u03cd\u03c0\u03bf\u03c5 \u03b1\u03b4\u03b5\u03bd\u03bf\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b3\u03b1\u03c3\u03c4\u03c1\u03bf\u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03ae\u03c2<br \/>\n3. \u03a3\u03c4\u03bf 5% \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5<br \/>\n4. \u03a3\u03c4\u03bf 50% \u03c4\u03bf\u03c5 \u03c0\u03bf\u03c1\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03b1\u03b4\u03b5\u03bd\u03bf\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03c9\u03bd \u03c3\u03b9\u03b5\u03bb\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03b1\u03b4\u03ad\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03ba \u03c0\u03bb\u03b5\u03b9\u03bf\u03bc\u03cc\u03c1\u03c6\u03bf\u03c5 \u03b1\u03b4\u03b5\u03bd\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2<br \/>\n5. \u03a3\u03c4\u03bf 25-30% \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03bc\u03b7\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u03bf\u03c1\u03ce\u03b4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-8 kit-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-8\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-8\" data-dismiss=\"modal\" aria-hidden=\"true\">KIT<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9: <\/b>\u03a4\u03bf KIT \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03ad\u03bd\u03b1\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b1 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 RAS, RAF \u03ba\u03b1\u03b9 \u039c\u0395\u039a \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7:<\/b><br \/>\n1. GIST: \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b5\u03c9\u03bd \u03c4\u03bf\u03c5 \u039a\u0399\u03a4 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 (\u03c0.\u03c7 imatinib, sunitinib)<br \/>\n2. \u039c\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1: \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b5\u03c9\u03bd \u03c4\u03bf\u03c5 \u039a\u0399\u03a4 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 (\u03c0.\u03c7 imatinib)<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1:<\/b><br \/>\n1. \u0391\u03bd\u03b5\u03c5\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c0\u03bb\u03b5\u03b9\u03cc\u03bd\u03bf\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd GIST; \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf 60% \u03c4\u03c9\u03bd GIST \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf 90% \u03c4\u03c9\u03bd \u03b5\u03be\u03c9\u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ce\u03bd GIST<br \/>\n2. \u03a3\u03c4\u03bf 1\/3 \u03c4\u03c9\u03bd \u03bc\u03b5\u03bb\u03b1\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03c9\u03bd \u03ac\u03ba\u03c1\u03c9\u03bd<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-9 pdgfra-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-9\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-9\" data-dismiss=\"modal\" aria-hidden=\"true\">PDGFRA<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9: <\/b>\u03a4\u03bf PDGFRA \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03ad\u03bd\u03b1\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b1 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 RAS, RAF \u03ba\u03b1\u03b9 \u039c\u0395\u039a \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7:<\/b><br \/>\nGIST: \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b5\u03c9\u03bd \u03c4\u03bf\u03c5 PDGFRA \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 (\u03c0.\u03c7 imatinib, sunitinib), \u03b5\u03bd\u03ce \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 D842V \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1: <\/b>\u03a0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 10% \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c4\u03c9\u03bd GIST, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03bf\u03c5.<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-10 kras-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-10\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-10\" data-dismiss=\"modal\" aria-hidden=\"true\">KRAS<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9:<\/b> \u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u03af\u03bd\u03b7 K-Ras \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf KRAS \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03bc\u03ae\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03bf\u03cd RAS\/MAPK, \u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03bc\u03cc. \u039f\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03ba\u03c9\u03b4\u03b9\u03ba\u03cc\u03bd\u03b9\u03b1 12 \u03ba\u03b1\u03b9 13.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7:<\/b><br \/>\n1. \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5: \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd KRAS (\u03ae NRAS) \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 anti-EGFR \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1.<br \/>\n2. \u039c\u039c\u039a\u03a0: \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 KRAS G12C \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 KRAS.<br \/>\n3. \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2: \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 KRAS (\u03ae NRAS\/HRAS) \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c0\u03b9\u03bf \u03ae\u03c0\u03b9\u03b1 \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1:<\/b> \u0395\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 40-50% \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf 30% \u03c4\u03c9\u03bd \u039c\u039c\u039a\u03a0, \u03bc\u03b5 \u03c4\u03bf 10-15% \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c4\u03bf\u03c5 KRAS-G12C.<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-11 mmr-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-11\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-11\" data-dismiss=\"modal\" aria-hidden=\"true\">MMR<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03af \u03b5\u03af\u03bd\u03b1\u03b9: <\/b>\u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03bf \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA (MMR) \u03c5\u03c0\u03b5\u03cd\u03b8\u03c5\u03bd\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03b2\u03bb\u03b1\u03b2\u03ce\u03bd \u03c4\u03bf\u03c5 DNA \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b5\u03c2 MLH1, PMS2, MSH2 \u03ba\u03b1\u03b9 MSH6. \u039a\u03b1\u03c4\u03ac \u03ba\u03b1\u03bd\u03cc\u03bd\u03b1 \u03c4\u03bf MLH1 \u03b1\u03c0\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03af\u03c4\u03b5 \u03b1\u03c0\u03cc \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 (\u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b3\u03b1\u03bc\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2) \u03ae \u03bc\u03ad\u03c3\u03c9 \u03c5\u03c0\u03b5\u03c1\u03bc\u03b5\u03b8\u03c5\u03bb\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03ba\u03ba\u03b9\u03bd\u03b7\u03c4\u03ae \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 (\u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae). \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03c4\u03b1 MSH2, PMS2 \u03ba\u03b1\u03b9 MSH6 \u03b1\u03c0\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b7\u03b8\u03ad\u03c3\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc \u03b3\u03b1\u03bc\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c4\u03cd\u03c0\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2.<br \/>\n\u03a4\u03b1 \u03b3\u03b1\u03bc\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c4\u03cd\u03c0\u03bf\u03c5 \u03c3\u03c6\u03ac\u03bb\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03bf MMR \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b1 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1:<br \/>\n1. Lynch syndrome (\u03b1\u03c5\u03c4\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03ae\u03c2 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1), \u03c0\u03bf\u03c5 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5, \u03b5\u03bd\u03b4\u03bf\u03bc\u03b7\u03c4\u03c1\u03af\u03bf\u03c5, \u03bf\u03c5\u03c1\u03bf\u03b8\u03b7\u03bb\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03bf\u03c5 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03c3\u03c9\u03bb\u03ae\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03bf\u03c2-\u03c7\u03bf\u03bb\u03b7\u03c6\u03cc\u03c1\u03c9\u03bd.<br \/>\n2. Muir-Torre syndrome (\u03b1\u03c5\u03c4\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03ba\u03c1\u03b1\u03c4\u03ae\u03c2 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1), \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c4\u03c9\u03bd \u03b1\u03bd\u03c9\u03c4\u03ad\u03c1\u03c9\u03bd \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03c9\u03bd \u03c3\u03bc\u03b7\u03b3\u03bc\u03b1\u03c4\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03b1\u03b4\u03ad\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ac \u03ba\u03b5\u03c1\u03b1\u03c4\u03bf\u03b1\u03ba\u03b1\u03bd\u03b8\u03ce\u03bc\u03b1\u03c4\u03b1.<br \/>\n3. \u0398\u03b5\u03bc\u03b5\u03bb\u03b9\u03ce\u03b4\u03b5\u03c2 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 MMR (\u03b1\u03c5\u03c4\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1), \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03bf\u03bd\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bd \u03c4\u03bf\u03c5 \u03af\u03b4\u03b9\u03bf\u03c5 \u03c4\u03cd\u03c0\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Lynch, \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2. \u03a3\u03c5\u03bd\u03b1\u03bd\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b7 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b5\u03c6\u03b7\u03b2\u03b9\u03ba\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1.<br \/>\n\u0388\u03bd\u03b1 \u03bd\u03b5\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03bf\u03c0\u03bf\u03b9\u03b1\u03c3\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 MMR \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b7\u03c2 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03ba\u03ce\u03c2 \u03b6\u03b5\u03c5\u03b3\u03b1\u03c1\u03c9\u03bc\u03ad\u03bd\u03c9\u03bd \u03b2\u03ac\u03c3\u03b5\u03c9\u03bd (MMR deficient-dMMR).<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7:<\/b><br \/>\n1. \u03a3\u03c4\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5, \u03bf\u03b9 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03ba\u03b1\u03c4\u03ac NICE (National Institute for Health and Clinical Excellence), \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c4\u03bf\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03ca\u03c3\u03c4\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b3\u03b9\u03b1 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 MMR \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03bf\u03b4\u03b9\u03b5\u03b3\u03bd\u03c9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2.<br \/>\n-\u0397 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03b3\u03b1\u03bc\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c4\u03cd\u03c0\u03bf\u03c5 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 MMR, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf \u03c4\u03b7\u03c2 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2.<br \/>\n&#8211; \u0397 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03c4\u03bf\u03c5 MMR \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03c9\u03bd \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<br \/>\n&#8211; \u0397 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03c4\u03bf\u03c5 MMR \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9, \u03b5\u03c0\u03af\u03c3\u03b7\u03c2, \u03bc\u03b9\u03b1 \u03c0\u03b9\u03bf \u03ae\u03c0\u03b9\u03b1 \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<br \/>\n2. \u03a3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03bc\u03b7\u03c4\u03c1\u03af\u03bf\u03c5, \u03bf\u03b9 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03ba\u03b1\u03c4\u03ac NICE, \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c4\u03bf\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03ca\u03c3\u03c4\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b3\u03b9\u03b1 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 MMR \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03bd\u03b5\u03bf\u03b4\u03b9\u03b5\u03b3\u03bd\u03c9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5\u03c2.<br \/>\n-\u0397 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03b3\u03b1\u03bc\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c4\u03cd\u03c0\u03bf\u03c5 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 MMR, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf \u03c4\u03b7\u03c2 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2.<br \/>\n&#8211; \u0397 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03c4\u03bf\u03c5 MMR \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03c9\u03bd \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1: <\/b><br \/>\n<b>1. <\/b>\u03a0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf 15% \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5, \u03b7 \u03c0\u03bb\u03b5\u03b9\u03bf\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03c4\u03cd\u03c0\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2. \u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03bf \u03b4\u03b5\u03be\u03b9\u03cc \u03ba\u03cc\u03bb\u03bf\u03bd, \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b2\u03bb\u03b5\u03bd\u03bd\u03ce\u03b4\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c0\u03bf\u03b9\u03ba\u03b9\u03bb\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 \u03b1\u03bd\u03bf\u03c3\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7.<br \/>\n2. \u03a0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 20-25% \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03bc\u03b7\u03c4\u03c1\u03af\u03bf\u03c5, \u03b7 \u03c0\u03bb\u03b5\u03b9\u03bf\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03c4\u03cd\u03c0\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2. \u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b5\u03bd\u03b4\u03bf\u03bc\u03b7\u03c4\u03c1\u03b9\u03bf\u03b5\u03b9\u03b4\u03ae \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03ba\u03c4\u03ac \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b1\u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03ae\u03bc\u03b5\u03bd\u03b1 \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03bc\u03b7\u03c4\u03c1\u03af\u03bf\u03c5. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c5\u03c8\u03b7\u03bb\u03cc\u03b2\u03b1\u03b8\u03bc\u03b7\u03c2 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 \u03b1\u03bd\u03bf\u03c3\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7.<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-12 msi-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-12\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-12\" data-dismiss=\"modal\" aria-hidden=\"true\">MSI<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03af \u03b5\u03af\u03bd\u03b1\u03b9:<\/b> \u039f\u03b9 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03bf\u03c1\u03c5\u03c6\u03cc\u03c1\u03bf\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b2\u03c1\u03b1\u03c7\u03b5\u03af\u03b5\u03c2 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b5\u03c2 DNA. \u0397 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03bf\u03c1\u03c5\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae \u03b1\u03c3\u03c4\u03ac\u03b8\u03b5\u03b9\u03b1 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03c3\u03b5 \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 MMR \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c8\u03b5\u03b9 \u03b5\u03af\u03c4\u03b5 \u03bc\u03ad\u03c3\u03c9 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03ae \u03b3\u03b1\u03bc\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ce\u03bd.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7: <\/b>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03af\u03b4\u03b9\u03b5\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03c4\u03bf\u03c5 MMR. \u0393\u03b5\u03bd\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b1, \u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03ca\u03c3\u03c4\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 MMR \u03ae \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03bf\u03c1\u03c5\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c3\u03c4\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2 (MSI) \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03bc\u03c6\u03cc\u03c4\u03b5\u03c1\u03b1.<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-13 nras-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-13\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-13\" data-dismiss=\"modal\" aria-hidden=\"true\">NRAS<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03af \u03b5\u03af\u03bd\u03b1\u03b9: <\/b>\u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf NRAS \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b7 N-Ras \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u2019 \u03b5\u03be\u03bf\u03c7\u03ae\u03bd \u03c3\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03b1\u03af\u03c1\u03b5\u03c3\u03b7\u03c2. \u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf NRAS \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c4\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9 RAS-RAF-MAPK \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc. \u039f\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03bf\u03c5\u03bd \u03c3\u03c4\u03b1 \u03ba\u03c9\u03b4\u03b9\u03ba\u03cc\u03bd\u03b9\u03b1 12 \u03ba\u03b1\u03b9 13.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7: <\/b><br \/>\n1. \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd NRAS (\u03ae KRAS) \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 anti-EGFR \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1.<br \/>\n2. \u039c\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd NRAS \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9, \u03b5\u03bd \u03bc\u03ad\u03c1\u03b5\u03b9, \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 MEK (\u03c0.\u03c7 trametinib).<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1:<\/b><br \/>\n1. \u0395\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 40-50% \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5<br \/>\n2. \u03a0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 15-20% \u03c4\u03c9\u03bd \u03bc\u03b5\u03bb\u03b1\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03bf\u03c5\u03bd \u03c4\u03cc\u03c3\u03bf \u03c3\u03c4\u03b9\u03c2 \u03b5\u03ba\u03c4\u03b9\u03b8\u03ad\u03bc\u03b5\u03bd\u03b5\u03c2 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03bc\u03b7-\u03b5\u03ba\u03c4\u03b9\u03b8\u03ad\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-14 pd-l1-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-14\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-14\" data-dismiss=\"modal\" aria-hidden=\"true\">PD-L1<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03af \u03b5\u03af\u03bd\u03b1\u03b9:<\/b> \u03a4\u03b1 \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c5\u03c0\u03bf\u03ba\u03c1\u03cd\u03c0\u03c4\u03bf\u03c5\u03bd \u03c0\u03bb\u03b7\u03b8\u03ce\u03c1\u03b1 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03b5\u03bb\u03b1\u03c4\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd (\u03bd\u03b5\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1). \u03a4\u03b1 \u03bd\u03b5\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03be\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf-\u03b5\u03c0\u03b1\u03b3\u03cc\u03bc\u03b5\u03bd\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03bf\u03c5\u03c2. \u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03cc\u03b3\u03ba\u03bf\u03b9 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 (immune checkpoints) \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03cc\u03c1\u03b9\u03b1 \u03c3\u03c4\u03b1 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03b5\u03af\u03c4\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2, \u03b5\u03af\u03c4\u03b5 \u03c4\u03b1 \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03b5 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2. \u039f\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03c9\u03bd \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c0\u03bf\u03c5\u03bd \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03b4\u03b5\u03bd \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf-\u03b5\u03c0\u03b1\u03b3\u03cc\u03bc\u03b5\u03bd\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03c9\u03bd \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7:<\/b><br \/>\n1. \u039c\u039c\u039a\u03a0: \u03a4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 PD-L1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bd\u03b1 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03b5\u03af\u03c4\u03b5 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 (\u0391\u03a3\u0395) \u03b5\u03af\u03c4\u03b5 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (pembrolizumab).<br \/>\n2. \u039f\u03c5\u03c1\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1: \u03a4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 PD-L1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u0391\u03a3\u0395 (atezolizumab, pembrolizumab).<br \/>\n3. \u03a0\u03bb\u03b1\u03ba\u03ce\u03b4\u03b5\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1 \u03ba\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2\/\u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5: \u03a4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 PD-L1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u0391\u03a3\u0395 (atezolizumab, nivolumab).<br \/>\n4. \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03bf\u03b9\u03c3\u03bf\u03c6\u03ac\u03b3\u03bf\u03c5: \u03a4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 PD-L1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u0391\u03a3\u0395 (atezolizumab, nivolumab).<br \/>\n5. \u03a4\u03c1\u03b9\u03c0\u03bb\u03ac \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd: \u03a4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 PD-L1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u0391\u03a3\u0395 (atezolizumab).<br \/>\n6. \u039c\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1: \u03a4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 PD-L1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bd\u03b1 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03b5\u03af\u03c4\u03b5 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u0391\u03a3\u0395 \u03b5\u03af\u03c4\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03b4\u03cd\u03bf \u0391\u03a3\u0395 (nivolumab \u03ae nivoluma-ipilimumab).<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-15 ret-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-15\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-15\" data-dismiss=\"modal\" aria-hidden=\"true\">RET<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03af \u03b5\u03af\u03bd\u03b1\u03b9: <\/b>\u03a4\u03bf \u03c0\u03c1\u03c9\u03c4\u03bf-\u03bf\u03b3\u03ba\u03bf\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf RET \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03ad\u03bd\u03b1\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b1 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 RAS, RAF \u03ba\u03b1\u03b9 \u039c\u0395\u039a \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7: <\/b><br \/>\n<b>1. <\/b>\u039c\u039c\u039a\u03a0: \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c3\u03c5\u03bd\u03c4\u03ae\u03be\u03b5\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 RET \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 RET (\u03c0.\u03c7 selpercatinib, pralsetinib)<br \/>\n2. \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2: \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c3\u03c5\u03bd\u03c4\u03ae\u03be\u03b5\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 RET \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 RET (selpercatinib)<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1:<\/b><br \/>\n<b>1. <\/b>\u0395\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 1-2% \u03c4\u03c9\u03bd \u039c\u039c\u039a\u03a0 \u03ba\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03b1 \u03b1\u03b4\u03b5\u03bd\u03bf\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c3\u03b5 \u03bc\u03b7-\u03ba\u03b1\u03c0\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2<br \/>\n2. \u0395\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 10-20% \u03c4\u03bf\u03c5 \u03b8\u03b7\u03bb\u03ce\u03b4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-16 ros1-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-16\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-16\" data-dismiss=\"modal\" aria-hidden=\"true\">ROS1<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03af \u03b5\u03af\u03bd\u03b1\u03b9: <\/b>\u03a4\u03bf \u03c0\u03c1\u03c9\u03c4\u03bf-\u03bf\u03b3\u03ba\u03bf\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf ROS1 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03ad\u03bd\u03b1\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b1 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 RAS, RAF \u03ba\u03b1\u03b9 \u039c\u0395\u039a \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7: <\/b>\u03a3\u03c4\u03bf \u039c\u039c\u039a\u03a0 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 ROS1 \u03b1\u03bd\u03b1\u03ba\u03b1\u03c4\u03b1\u03c4\u03ac\u03be\u03b5\u03c9\u03bd \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 (\u03c0.\u03c7 crizotinib)<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1:<\/b> \u0395\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 1% \u03c4\u03c9\u03bd \u039c\u039c\u039a\u03a0, \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b1 \u03b1\u03b4\u03b5\u03bd\u03bf\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b7-\u03ba\u03b1\u03c0\u03bd\u03af\u03c3\u03c4\u03c1\u03b9\u03b5\u03c2<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-17 pik3ca-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-17\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-17\" data-dismiss=\"modal\" aria-hidden=\"true\">PIK3CA<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03af \u03b5\u03af\u03bd\u03b1\u03b9: <\/b>\u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf PIK3CA \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1-\u03c5\u03c0\u03bf\u03bc\u03bf\u03bd\u03ac\u03b4\u03b1 \u03c4\u03bf\u03c5 PI3K \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03bf\u03cd \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ad\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03bf\u03bd \u03b1\u03bd\u03b5\u03be\u03ad\u03bb\u03b5\u03b3\u03ba\u03c4\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc. \u039f\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b5\u03be\u03ce\u03bd\u03b9\u03bf 9 \u03ba\u03b1\u03b9 20.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7:<\/b><br \/>\n1. Luminal A \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd: \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 PIK3CA \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 PIK3CA (\u03c0.\u03c7 alpelisib)<br \/>\n2. MMKP:<span class=\"Apple-converted-space\">\u00a0 <\/span>\u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 PIK3CA \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 PIK3CA<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1: <\/b><br \/>\n1. \u0395\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 30-40% \u03c4\u03c9\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03bf-\u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<br \/>\n2. E\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc 5% \u03c4\u03c9\u03bd \u039c\u039c\u039a\u03a0 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b1 \u03c0\u03bb\u03b1\u03ba\u03ce\u03b4\u03b7 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-18 nrtk-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-18\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-18\" data-dismiss=\"modal\" aria-hidden=\"true\">NTRK<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03af \u03b5\u03af\u03bd\u03b1\u03b9:<\/b> \u03a4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 NTRK1, NTRK2 \u03ba\u03b1\u03b9 NTRK3 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 TrkA, TrkB \u03ba\u03b1\u03b9 \u03a4rkC. \u0397 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b1 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 RAS, RAF \u03ba\u03b1\u03b9 \u039c\u0395\u039a \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc. \u039f\u03b9 \u03b4\u03b9\u03b1\u03bc\u03b5\u03c4\u03b1\u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 \u03c3\u03cd\u03bd\u03c4\u03b7\u03be\u03b7 NTRK \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03c9\u03bd \u03b1\u03bd\u03b5\u03be\u03ad\u03bb\u03b5\u03b3\u03ba\u03c4\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7:<\/b><br \/>\n\u039c\u039c\u039a\u03a0: \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c3\u03c5\u03bd\u03c4\u03ae\u03be\u03b5\u03c9\u03bd NTRK \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1:<\/b> \u0395\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 1,7% \u03c4\u03c9\u03bd \u039c\u039c\u039a\u03a0<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-19 met-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-19\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-19\" data-dismiss=\"modal\" aria-hidden=\"true\">MET<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03af \u03b5\u03af\u03bd\u03b1\u03b9:<\/b> \u03a4\u03bf \u03c0\u03c1\u03c9\u03c4\u03bf-\u03bf\u03b3\u03ba\u03bf\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf MET \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03ad\u03bd\u03b1\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b1 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 RAS, RAF \u03ba\u03b1\u03b9 \u039c\u0395\u039a \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7:<\/b> \u0397 \u03b4\u03b9\u03b5\u03b8\u03bd\u03ae\u03c2 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03c0\u03c9\u03c2 \u03bf\u03b9 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf MET \u03c3\u03c4\u03b1 \u039c\u039c\u039a\u03a0 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2, \u03c7\u03c9\u03c1\u03af\u03c2 \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03b5\u03b8\u03b5\u03af \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03ba\u03b1\u03c4\u03ac NICE. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03b7 \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c3\u03c4\u03bf \u039c\u0395\u03a4 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03c0\u03b1\u03b8\u03bf\u03cd\u03c2 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b1 EGFR \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03b1 \u039c\u039c\u039a\u03a0.<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1:<\/b> \u0395\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 5% \u03c4\u03c9\u03bd \u039c\u039c\u039a\u03a0.<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-20 men1-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-20\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-20\" data-dismiss=\"modal\" aria-hidden=\"true\">MEN1 <\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9<\/b>: \u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf MEN1 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b7 \u03bc\u03b5\u03bd\u03af\u03bd\u03b7, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1 \u03bf\u03b3\u03ba\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03c4\u03b5\u03af \u03bc\u03b5 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03bf\u03cd\u03c2 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03af\u03b1\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 1. \u0397 \u03bc\u03b5\u03bd\u03af\u03bd\u03b7 \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac \u03c3\u03c4\u03b7 \u03b4\u03bf\u03bc\u03ae \u03c4\u03b7\u03c2 \u03c7\u03c1\u03c9\u03bc\u03b1\u03c4\u03af\u03bd\u03b7\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03bf\u03bd\u03ce\u03bd.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/b>: \u0395\u03bb\u03ad\u03b3\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03c5\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c3\u03c5\u03bd\u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 MEN1.<br \/>\n<b>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1:<\/b> \u0395\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 1 \u03c3\u03c4\u03bf\u03c5\u03c2 30.000 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2.<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-21 mdm2-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-21\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-21\" data-dismiss=\"modal\" aria-hidden=\"true\">MDM2<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\"><b>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9:<\/b> \u03a4\u03bf \u03c0\u03c1\u03c9\u03c4\u03bf\u03bf\u03b3\u03ba\u03bf\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf MDM2 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b7 Mdm2 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b4\u03c1\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf \u03bf\u03b3\u03ba\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf p53.<br \/>\n<b>\u0393\u03b9\u03b1\u03c4\u03af \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7:<\/b> \u0397 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 MDM2 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9, \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03ac\u03bb\u03bb\u03c9\u03bd, \u03c3\u03c4\u03bf\u03bd \u03ac\u03c4\u03c5\u03c0\u03bf \u03bb\u03b9\u03c0\u03c9\u03bc\u03b1\u03c4\u03ce\u03b4\u03b7 \u03cc\u03b3\u03ba\u03bf\/\u03ba\u03b1\u03bb\u03ac \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03bb\u03b9\u03c0\u03bf\u03c3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b1\u03c0\u03bf\u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03bb\u03b9\u03c0\u03bf\u03c3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1, \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b9\u03bc\u03b7\u03c4\u03ad\u03c2 \u03c4\u03bf\u03c5\u03c2.<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-22 hpv-anixneusi-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-22\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-22\" data-dismiss=\"modal\" aria-hidden=\"true\">HPV \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03c5\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\">\u0391\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd \u03c4\u03c9\u03bd \u03b1\u03bd\u03b8\u03c1\u03c9\u03c0\u03af\u03bd\u03c9\u03bd \u03b8\u03b7\u03bb\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (HPV) \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf PCR \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03c4\u03c5\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c4\u03b5\u03bb\u03b5\u03c7\u03ce\u03bd \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd HPV. \u039c\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf \u03b5\u03bd\u03b4\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf \u03bc\u03cc\u03bb\u03c5\u03bd\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b9\u03cc HPV \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b2\u03bf\u03bb\u03ae \u03b1\u03c0\u03cc \u03c7\u03b1\u03bc\u03b7\u03bb\u03bf\u03cd \u03ae \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c3\u03c4\u03b5\u03bb\u03ad\u03c7\u03b7 \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd.<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-23 panel-prodiathesis-karkinou-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-23\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-23\" data-dismiss=\"modal\" aria-hidden=\"true\">Panel \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\">Panel<b> <\/b>\u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 17 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5. \u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7\u03c2 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ac\u03c2 (NGS) \u03ba\u03b1\u03b9 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 <i>APC, MLH1, MSH2, MSH6, BMPR1A, CDH1, CHECK2, EPCAM, SMAD4, STK11, TP53, GREM1, MUTYH, PMS2, POLD1, POLE, PTEN<\/i>.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-24 panel-sindromou-lynch-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-24\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-24\" data-dismiss=\"modal\" aria-hidden=\"true\">Panel \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 Lynch<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\">Panel \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03bc\u03b7 \u03c0\u03bf\u03bb\u03c5\u03c0\u03bf\u03b4\u03b9\u03b1\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5 (\u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Lynch). \u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7\u03c2 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ac\u03c2 (NGS) \u03ba\u03b1\u03b9 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 <i>EPCAM, MLH1, MSH2, MSH6 \u03ba\u03b1\u03b9 PSM2<\/i>.<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-25 panel-sindromou-polipodiasis-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-25\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-25\" data-dismiss=\"modal\" aria-hidden=\"true\">Panel \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03c0\u03bf\u03bb\u03c5\u03c0\u03bf\u03b4\u03af\u03b1\u03c3\u03b7\u03c2<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\">Panel \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 8 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03b1\u03b4\u03b5\u03bd\u03c9\u03bc\u03b1\u03c4\u03ce\u03b4\u03bf\u03c5\u03c2 \u03c0\u03bf\u03bb\u03c5\u03c0\u03bf\u03b4\u03af\u03b1\u03c3\u03b7\u03c2 (FAP). \u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7\u03c2 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ac\u03c2 (NGS) \u03ba\u03b1\u03b9 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 <i>BMPR1A, APC, MUTYH, NTHL1, POLE, POLD1, STK11, SMAD4<\/i>.<\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-26 panel-prodiathesis-gastrikou-karkinou-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-26\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-26\" data-dismiss=\"modal\" aria-hidden=\"true\">Panel \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5\u2028<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\">Panel<b> <\/b>\u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 14 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b3\u03b1\u03c3\u03c4\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf. \u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7\u03c2 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ac\u03c2 (NGS) \u03ba\u03b1\u03b9 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 <i>CDH1, SDHB, SDHC, SDHD, SMAD4, STK11, APC, BMPR1A, EPCAM, MLH1, MSH2, MSH6, PMS2, TP53.<\/i><\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-27 panel-prodiathesis-karkinou-pagkreatos-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-27\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-27\" data-dismiss=\"modal\" aria-hidden=\"true\">Panel \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\">Panel<b> <\/b>\u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 17 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2. \u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7\u03c2 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ac\u03c2 (NGS) \u03ba\u03b1\u03b9 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 <i>APC, PALB2, SMAD4, ATM, BMPR1A, BRCA1, BRCA2, CDK4, STK11, TP53, PMS2, CDKN2A, EPCAM, MEN1, MLH1, MSH2, MSH6.<\/i><\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-28 panel-prodiathesis-karkinou-mastou-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-28\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-28\" data-dismiss=\"modal\" aria-hidden=\"true\">Panel \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd\/\u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\">Panel<b> <\/b>\u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 26 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2. \u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7\u03c2 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ac\u03c2 (NGS) \u03ba\u03b1\u03b9 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1<span class=\"Apple-converted-space\">\u00a0 <\/span><i>BRCA1, BRCA2, BRIP1, PALB2, PMS2, POLD1, POLE, PTEN, RAD50, RAD51C, RAD51D, SMARCA4, STK11, TP53, CDH1, CHEK2, DICER1, \u0391\u03a4\u039c, \u0392\u0391RD1, EPCAM, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN.<\/i><\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><div class=\"fusion-modal modal fade modal-29 panel-prodiathesis-melanwmatos-modal modal-design\" tabindex=\"-1\" role=\"dialog\" aria-labelledby=\"modal-heading-29\" aria-hidden=\"true\" style=\"--awb-border-color:var(--awb-color1);--awb-background:var(--awb-color1);\"><div class=\"modal-dialog modal-lg\" role=\"document\"><div class=\"modal-content fusion-modal-content\"><div class=\"modal-header\"><button class=\"close\" type=\"button\" data-dismiss=\"modal\" aria-hidden=\"true\" aria-label=\"Close\">&times;<\/button><h3 class=\"modal-title\" id=\"modal-heading-29\" data-dismiss=\"modal\" aria-hidden=\"true\">Panel \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03bf\u03c5\u03c2 \u03bc\u03b5\u03bb\u03b1\u03bd\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2<\/h3><\/div><div class=\"modal-body fusion-clearfix\">\n<p class=\"p1\">Panel<b> <\/b>\u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 7 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf \u03ba\u03b1\u03ba\u03cc\u03b7\u03b8\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1. \u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7\u03c2 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ac\u03c2 (NGS) \u03ba\u03b1\u03b9 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 <i>\u0392\u0391P1, CDKN2A, PTEN, RB1, BRCA2, CDK4, TP53.<\/i><\/p>\n<\/div><div class=\"modal-footer\"><button class=\"fusion-button button-default button-medium button default medium\" type=\"button\" data-dismiss=\"modal\">Close<\/button><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-1659","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 - Istomedica<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/istomedica.gr\/el\/molecular-tests\/\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" 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